[Chemical Name]: |
Valsartan/sacubitril; LCZ-696; LCZ 696 |
[Synonyms ]: |
Entresto; L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1'-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5); trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3-methyl-2-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4-ylmethyl}amino)butyrate] hemipentahydrate; trisodium 3-((1S,3R)-1-(biphenyl-4-ylmethyl)-3-(ethoxycarbonyl)butylcarbamoyl)propionate (S)-3-methyl-2-(pentanoyl-(2-(tetrazol-1-at-5-yl)biphenyl-4'-ylmethyl)amino)butyrate hemipentahydrate |
[CAS No.]: |
936623-90-4 |
[Structure Formula]: | |
[Molecular Formula]: |
C48H55N6Na3O8 / C48H55N6O8(-3) |
[Molecular Weight]: |
843.99 |
[Solubility]: |
in DMSO > 10 mM |
[Purity ( Assay ) ]: |
99.0% min |
[Biological activity ]: |
LCZ696 is a first-in-class dual inhibitor of the angiotensin II receptor(AT II receptor) and neprilysin; a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio). |
[Usage/Application]: |
LCZ696 is used for the treatment of heart failure , LCZ696 is believed to be able to reduce the pressure of heart failure, and promote heart muscle ability |
[Packing]: |
In small aluminum foil bag or 1kg-10kg Tin |